MolNFT v1 · #177377 · protein
The srm module of SWI/SNF-nucleosome complex
7EGM · Transcription regulatory protein SNF2: “The srm module of SWI/SNF-nucleosome complex”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #177377 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EGM
- Type
- protein
- Length
- 2,431 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription regulatory protein SNF2; SWI/SNF chromatin-remodeling complex subunit SWI1…
- EC
- 3.6.4.-
- UniProt
- P22082, P09547, P18480, P32591, P53628, P18888, P43554
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 8 distinct chains · 48% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription regulatory protein SNF2 (EC 3.6.4.-) | protein | 109 | 61% helix, 0% strand | P22082 |
| B | SWI/SNF chromatin-remodeling complex subunit SWI1 | protein | 507 | 56% helix, 1% strand | P09547 |
| C | SWI/SNF chromatin-remodeling complex subunit SNF5 | protein | 337 | 31% helix, 12% strand | P18480 |
| D | SWI/SNF complex subunit SWI3 | protein | 395 | 52% helix, 1% strand | P32591 |
| H | Transcription regulatory protein SNF12 | protein | 388 | 39% helix, 14% strand | P53628 |
| I | Transcription regulatory protein SNF6 | protein | 106 | 42% helix, 0% strand | P18888 |
| J | SWI/SNF global transcription activator complex subunit SWP82 | protein | 167 | 39% helix, 2% strand | P43554 |
| E | SWI/SNF complex subunit SWI3 | protein | 422 | 60% helix, 1% strand | P32591 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 191 | 0.80 | 0.94 | 29 | empty |
| 2 | 1015 | 0.79 | 0.81 | 95 | empty |
| 3 | 734 | 0.79 | 0.83 | 66 | empty |
| 4 | 354 | 0.77 | 0.87 | 48 | empty |
| 5 | 830 | 0.76 | 0.80 | 66 | empty |
Interfaces
26 interfaces between chains.
- D–E · 5664 Ų buried · 36 hydrogen bonds · protein-protein
- D–H · 3473 Ų buried · 20 hydrogen bonds · protein-protein
- C–E · 3196 Ų buried · 36 hydrogen bonds · protein-protein
- H–E · 2901 Ų buried · 17 hydrogen bonds · protein-protein
- B–H · 2649 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 7EGM · The SRM module of SWI/SNF-nucleosome complex · the same entry in another collection · chain E against E, TM-score 1.00
- P09547 · AlphaFold monomer V2.0 prediction for SWI/SNF chromatin-remodeling complex subunit SWI1… · a predicted model of the same protein · chain B against A, TM-score 0.93
- P18480 · AlphaFold monomer V2.0 prediction for SWI/SNF chromatin-remodeling complex subunit SNF5… · a predicted model of the same protein · chain C against A, TM-score 0.74
- P43554 · AlphaFold monomer V2.0 prediction for SWI/SNF global transcription activator complex… · a predicted model of the same protein · chain J against A, TM-score 0.62
- P22082 · AlphaFold monomer V2.0 prediction for transcription regulatory protein SNF2 (P22082) · a predicted model of the same protein · chain A against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22082
- Every structure of UniProt P09547
- Every structure of UniProt P18480
- Every structure of UniProt P32591
- Every structure of UniProt P53628
- Every structure of UniProt P18888
- Every structure of UniProt P43554
- Elsewhere: RCSB PDB 7EGM · PDBe 7EGM · UniProt P22082 · UniProt P09547 · UniProt P18480 · UniProt P32591 · UniProt P53628 · UniProt P18888 · UniProt P43554
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