MolNFT v1 · #177311 · protein

Structure of rift valley fever virus RNA-dependent RNA polymerase

7EEI · Replicase: “Structure of rift valley fever virus RNA-dependent RNA polymerase”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #177311 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EEI
Type: protein
Length: 1,400 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Replicase
EC: 2.7.7.48
UniProt: A2SZS3
Pockets: 20 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 45% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Replicase (EC 2.7.7.48)	protein	1400	45% helix, 7% strand	A2SZS3

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1028	0.83	0.84	140	empty
2	1049	0.81	0.82	128	empty
3	878	0.80	0.82	87	empty
4	52	0.70	0.98	18	empty
5	71	0.69	0.95	23	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7EEI · Structure of Rift Valley fever virus RNA-dependent RNA polymerase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A2SZS3
Elsewhere: RCSB PDB 7EEI · PDBe 7EEI · UniProt A2SZS3

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