MolNFT v1 · #177290 · protein

Crystal structure of AF10-DOT1L complex

7EDP · Histone-lysine N-methyltransferase, H3 lysine-79 specific: “Crystal structure of AF10-DOT1L complex”. X-ray diffraction. MolNFT v1 #177290 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EDP
Type: protein
Length: 83 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histone-lysine N-methyltransferase, H3 lysine-79 specific; Protein af-10
EC: 2.1.1.360
UniProt: Q8TEK3, Q5JT35

Structure

x-ray diffraction · 2 distinct chains · 92% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360)	protein	40	95% helix, 0% strand	Q8TEK3
A	Protein af-10	protein	43	88% helix, 0% strand	Q5JT35

Interfaces

1 interface between chains.

B–A · 958 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7EDP · Crystal structure of AF10-DOT1L complex · the same entry in another collection · chain B against B, TM-score 1.00
Q8TEK3 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-79… · a predicted model of the same protein · chain B against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TEK3
Every structure of UniProt Q5JT35
Elsewhere: RCSB PDB 7EDP · PDBe 7EDP · UniProt Q8TEK3 · UniProt Q5JT35

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