MolNFT v1 · #177183 · protein
Crystal structure of NAP1 lir in complex with gabarap
7EA7 · Gamma-aminobutyric acid receptor-associated protein: “Crystal structure of NAP1 lir in complex with gabarap”. X-ray diffraction, 3 pockets (best druggability 0.41). MolNFT v1 #177183 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7EA7
- Type
- protein
- Length
- 238 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric acid receptor-associated protein; NAP1_LIR motif
- UniProt
- O95166
- Pockets
- 3 · best druggability 0.41
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gamma-aminobutyric acid receptor-associated protein | protein | 116 | 34% helix, 22% strand | O95166 |
| B | Gamma-aminobutyric acid receptor-associated protein | protein | 114 | 29% helix, 23% strand | O95166 |
| C | NAP1_LIR motif | protein | 8 | 0% helix, 25% strand | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.41 | 0.76 | 26 | empty |
| 2 | 96 | 0.36 | 0.74 | 15 | empty |
| 3 | 57 | 0.32 | 0.76 | 11 | empty |
Interfaces
2 interfaces between chains.
- A–B · 579 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 472 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7EA7 · crystal structure of NAP1 LIR in complex with GABARAP · the same entry in another collection · chain A against A, TM-score 1.00
- O95166 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated protein… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95166
- Elsewhere: RCSB PDB 7EA7 · PDBe 7EA7 · UniProt O95166
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