MolNFT v1 · #177177 · protein
Crystal structure of SPINDLIN1 bound to spindoc DOCPEP2
7EA1 · Spindlin-1: “Crystal structure of SPINDLIN1 bound to spindoc DOCPEP2”. X-ray diffraction, 6 pockets (best druggability 0.51). MolNFT v1 #177177 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EA1
- Type
- protein
- Length
- 391 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spindlin-1; Peptide from spindlin interactor and repressor of chromatin-binding protein
- UniProt
- Q9Y657, Q9BUA3
- Pockets
- 6 · best druggability 0.51
Structure
x-ray diffraction · 4 distinct chains · 5% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spindlin-1 | protein | 200 | 7% helix, 48% strand | Q9Y657 |
| B | Peptide from spindlin interactor and repressor of chromatin-binding protein | protein | 5 | 0% helix, 0% strand | Q9BUA3 |
| C | Spindlin-1 | protein | 184 | 2% helix, 36% strand | Q9Y657 |
| D | Peptide from spindlin interactor and repressor of chromatin-binding protein | protein | 2 | 0% helix, 0% strand | Q9BUA3 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.51 | 0.79 | 19 | empty |
| 2 | 136 | 0.50 | 0.79 | 25 | empty |
| 3 | 250 | 0.48 | 0.73 | 32 | empty |
| 4 | 115 | 0.43 | 0.77 | 17 | empty |
| 5 | 99 | 0.39 | 0.76 | 18 | empty |
Interfaces
4 interfaces between chains.
- A–C · 722 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 372 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 201 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 110 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7EA1 · Crystal Structure of Spindlin1 bound to SPINDOC Docpep2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y657 · AlphaFold monomer V2.0 prediction for spindlin-1 (Q9Y657) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q9BUA3 · AlphaFold monomer V2.0 prediction for spindlin interactor and repressor of… · a predicted model of the same protein · chain B against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y657
- Every structure of UniProt Q9BUA3
- Elsewhere: RCSB PDB 7EA1 · PDBe 7EA1 · UniProt Q9Y657 · UniProt Q9BUA3
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