MolNFT v1 · #177122 · protein
Cryoem structure of the human KV4.2-DPP6S complex, transmembrane and intracellular region
7E87 · Potassium voltage-gated channel subfamily D member 2: “Cryoem structure of the human KV4.2-DPP6S complex, transmembrane and intracellular region”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #177122 on…
- PDB
- 7E87
- Type
- protein
- Length
- 1,664 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily D member 2; Dipeptidyl aminopeptidase-like…
- UniProt
- Q9NZV8, P42658
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 3 distinct chains · 64% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, C | Potassium voltage-gated channel subfamily D member 2 | protein | 388 | 62% helix, 4% strand | Q9NZV8 |
| A, D | Potassium voltage-gated channel subfamily D member 2 | protein | 388 | 64% helix, 3% strand | Q9NZV8 |
| J, I, E, F | Dipeptidyl aminopeptidase-like protein 6 | protein | 28 | 82% helix, 0% strand | P42658 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1086 | 0.82 | 0.82 | 72 | empty |
| 2 | 692 | 0.81 | 0.85 | 61 | empty |
| 3 | 707 | 0.71 | 0.77 | 80 | empty |
| 4 | 564 | 0.69 | 0.78 | 64 | empty |
| 5 | 579 | 0.66 | 0.75 | 52 | empty |
Interfaces
10 interfaces between chains.
- B–D · 2768 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 2766 Ų buried · 21 hydrogen bonds · protein-protein
- B–A · 2721 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 2709 Ų buried · 26 hydrogen bonds · protein-protein
- C–E · 447 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7E87 · CryoEM structure of the human Kv4.2-DPP6S complex, transmembrane and intracellular region · the same entry in another collection · chain F against F, TM-score 1.00
- Q9NZV8 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily D member… · a predicted model of the same protein · chain B against A, TM-score 0.82
- P42658 · AlphaFold monomer V2.0 prediction for dipeptidyl aminopeptidase-like protein 6 (P42658) · a predicted model of the same protein · chain I against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZV8
- Every structure of UniProt P42658
- Elsewhere: RCSB PDB 7E87 · PDBe 7E87 · UniProt Q9NZV8 · UniProt P42658
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