MolNFT v1 · #177118 · protein

Cryoem structure of the human KV4.2-KCHIP1 complex, intracellular region

7E83 · Potassium voltage-gated channel subfamily D member 2: “Cryoem structure of the human KV4.2-KCHIP1 complex, intracellular region”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #177118 on GenesisL1: 3D…

PDB: 7E83
Type: protein
Length: 1,544 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potassium voltage-gated channel subfamily D member 2; Kv channel-interacting protein 1
UniProt: Q9NZV8, Q9NZI2
Pockets: 20 · best druggability 0.81

Structure

electron microscopy · 2 distinct chains · 53% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, A, D, G	Potassium voltage-gated channel subfamily D member 2	protein	209	51% helix, 9% strand	Q9NZV8
E, B, F, H	Kv channel-interacting protein 1	protein	177	56% helix, 4% strand	Q9NZI2

Pockets

20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	548	0.81	0.87	42	empty
2	1172	0.75	0.77	87	empty
3	1198	0.74	0.77	92	empty
4	1094	0.74	0.77	85	empty
5	1181	0.74	0.77	91	empty

Interfaces

12 interfaces between chains.

C–A · 1941 Å² buried · 20 hydrogen bonds · protein-protein
C–G · 1936 Å² buried · 20 hydrogen bonds · protein-protein
D–G · 1934 Å² buried · 20 hydrogen bonds · protein-protein
A–D · 1933 Å² buried · 20 hydrogen bonds · protein-protein
D–H · 1812 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

7E83 · CryoEM structure of the human Kv4.2-KChIP1 complex, intracellular region · the same entry in another collection · chain H against H, TM-score 1.00
Q9NZI2 · AlphaFold monomer V2.0 prediction for kv channel-interacting protein 1 (Q9NZI2) · a predicted model of the same protein · chain E against A, TM-score 0.86
Q9NZV8 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily D member… · a predicted model of the same protein · chain C against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NZV8
Every structure of UniProt Q9NZI2
Elsewhere: RCSB PDB 7E83 · PDBe 7E83 · UniProt Q9NZV8 · UniProt Q9NZI2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.