MolNFT v1 · #177035 · protein

Human ppar alpha ligand binding domain in complex with APHM6 obtained by cocrystallization

7E5H · Peroxisome proliferator-activated receptor alpha: “Human ppar alpha ligand binding domain in complex with APHM6 obtained by cocrystallization”. X-ray diffraction, 1 ligand (HW3), 2 pockets (best druggability 0.84). MolNFT v1 #177035…

PDB: 7E5H
Type: protein
Length: 264 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisome proliferator-activated receptor alpha
UniProt: Q07869
Ligands: HW3
Pockets: 2 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome proliferator-activated receptor alpha	protein	264	68% helix, 5% strand	Q07869

Ligands and binding sites

HW3 · (2S)-2-[[3-[[3-fluoranyl-4-(4-fluoranylphenoxy) phenyl]methylcarbamoyl]-4-methoxy-phenyl]methyl]butanoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	477	0.84	0.91	51	HW3
2	71	0.31	0.74	13	empty

Compared structures

7E5H · Human ppar alpha ligand binding domain in complex with APHM6 obtained by cocrystallization · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07869
Elsewhere: RCSB PDB 7E5H · PDBe 7E5H · UniProt Q07869

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.