MolNFT v1 · #177029 · protein
Interferon-inducible anti-viral protein R356A
7E5A · Guanylate-binding protein 5: “Interferon-inducible anti-viral protein R356A”. X-ray diffraction, 3 ligands (GDP, AF3, MG), 12 pockets (best druggability 0.86). MolNFT v1 #177029 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7E5A
- Type
- protein
- Length
- 936 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanylate-binding protein 5
- EC
- 3.6.5.-
- UniProt
- Q96PP8
- Ligands
- GDP, AF3, MG
- Pockets
- 12 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanylate-binding protein 5 (EC 3.6.5.-) | protein | 465 | 54% helix, 14% strand | Q96PP8 |
| B | Guanylate-binding protein 5 (EC 3.6.5.-) | protein | 471 | 54% helix, 14% strand | Q96PP8 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
- AF3 · Aluminum fluoride · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 580 | 0.86 | 0.91 | 78 | GDP, AF3, MG |
| 2 | 1155 | 0.85 | 0.86 | 91 | empty |
| 3 | 100 | 0.58 | 0.86 | 18 | empty |
| 4 | 98 | 0.56 | 0.85 | 16 | empty |
| 5 | 353 | 0.56 | 0.75 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 3995 Ų buried · 46 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96PP8
- Elsewhere: RCSB PDB 7E5A · PDBe 7E5A · UniProt Q96PP8
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