MolNFT v1 · #177027 · protein
Interferon-inducible anti-viral protein 2
7E58 · Guanylate-binding protein 2: “Interferon-inducible anti-viral protein 2”. X-ray diffraction, 11 pockets (best druggability 0.71). MolNFT v1 #177027 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7E58
- Type
- protein
- Length
- 1,101 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanylate-binding protein 2
- EC
- 3.6.5.-
- UniProt
- P32456
- Pockets
- 11 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanylate-binding protein 2 (EC 3.6.5.-) | protein | 549 | 63% helix, 12% strand | P32456 |
| B | Guanylate-binding protein 2 (EC 3.6.5.-) | protein | 552 | 63% helix, 12% strand | P32456 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 612 | 0.71 | 0.79 | 57 | empty |
| 2 | 665 | 0.71 | 0.78 | 67 | empty |
| 3 | 441 | 0.68 | 0.80 | 51 | empty |
| 4 | 398 | 0.68 | 0.80 | 47 | empty |
| 5 | 115 | 0.40 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 12 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32456
- Elsewhere: RCSB PDB 7E58 · PDBe 7E58 · UniProt P32456
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