MolNFT v1 · #177020 · protein
Crystal structure of human microplasmin in complex with kazal-type inhibitor aati
7E50 · AAEL006007-pa: “Crystal structure of human microplasmin in complex with kazal-type inhibitor aati”. X-ray diffraction, 1 ligand (NA), 3 pockets (best druggability 0.39). MolNFT v1 #177020 on GenesisL1: 3D structure, binding sites…
- PDB
- 7E50
- Type
- protein
- Length
- 300 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- AAEL006007-pa; Plasminogen
- EC
- 3.4.21.7
- UniProt
- Q1HRB8, P00747
- Ligands
- NA
- Pockets
- 3 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | AAEL006007-pa | protein | 55 | 25% helix, 20% strand | Q1HRB8 |
| B | Plasminogen (EC 3.4.21.7) | protein | 245 | 9% helix, 36% strand | P00747 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.39 | 0.74 | 21 | empty |
| 2 | 101 | 0.36 | 0.74 | 22 | empty |
| 3 | 52 | 0.30 | 0.76 | 13 | GOL, NA |
Interfaces
1 interface between chains.
- A–B · 638 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 7E50 · Crystal structure of human microplasmin in complex with kazal-type inhibitor AaTI · the same entry in another collection · chain A against A, TM-score 1.00
- P00747 · AlphaFold monomer V2.0 prediction for plasminogen (P00747) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1HRB8
- Every structure of UniProt P00747
- Elsewhere: RCSB PDB 7E50 · PDBe 7E50 · UniProt Q1HRB8 · UniProt P00747
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