MolNFT v1 · #176900 · protein
Structure of dimeric upar
7E17 · Urokinase plasminogen activator surface receptor: “Structure of dimeric upar”. X-ray diffraction, 1 ligand (NAG), 8 pockets (best druggability 0.62). MolNFT v1 #176900 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7E17
- Type
- protein
- Length
- 457 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Urokinase plasminogen activator surface receptor
- UniProt
- Q03405
- Ligands
- NAG
- Pockets
- 8 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Urokinase plasminogen activator surface receptor | protein | 225 | 9% helix, 44% strand | Q03405 |
| B | Urokinase plasminogen activator surface receptor | protein | 232 | 8% helix, 42% strand | Q03405 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 295 | 0.62 | 0.79 | 50 | empty |
| 2 | 176 | 0.61 | 0.83 | 30 | empty |
| 3 | 465 | 0.60 | 0.75 | 56 | empty |
| 4 | 295 | 0.59 | 0.78 | 41 | empty |
| 5 | 78 | 0.45 | 0.81 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 3985 Ų buried · 84 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 25 disulfide, 6 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03405
- Elsewhere: RCSB PDB 7E17 · PDBe 7E17 · UniProt Q03405
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.