MolNFT v1 · #17686 · protein
Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase
1P14: “Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase”. X-ray diffraction, 4 pockets (best druggability 0.57). MolNFT v1 #17686 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1P14
- Type
- protein
- Length
- 287 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor
- EC
- 2.7.1.112
- UniProt
- P06213
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin receptor (EC 2.7.1.112) | protein | 287 | 38% helix, 17% strand | P06213 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 74 | 0.57 | 0.87 | 18 | empty |
| 2 | 185 | 0.55 | 0.80 | 27 | empty |
| 3 | 93 | 0.44 | 0.79 | 22 | empty |
| 4 | 78 | 0.32 | 0.74 | 16 | empty |
Compared structures
- 1P14 · Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase · the same entry in another collection · chain A against A, TM-score 1.00
- P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Elsewhere: RCSB PDB 1P14 · PDBe 1P14 · UniProt P06213
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