MolNFT v1 · #1767 · protein
Methods used in the structure determination of foot and mouth disease virus
1BBT · Foot-and-mouth disease virus (subunit VP1): “Methods used in the structure determination of foot and mouth disease virus”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #1767 on GenesisL1: 3D structure, binding…
- PDB
- 1BBT
- Type
- protein
- Length
- 662 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Foot-and-mouth disease virus (subunit VP1); Foot-and-mouth disease virus (subunit VP2)…
- UniProt
- Q84771, O90754
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 12% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1 | Foot-and-mouth disease virus (subunit VP1) | protein | 186 | 15% helix, 30% strand | Q84771 |
| 2 | Foot-and-mouth disease virus (subunit VP2) | protein | 210 | 10% helix, 45% strand | Q84771 |
| 3 | Foot-and-mouth disease virus (subunit VP3) | protein | 220 | 9% helix, 33% strand | Q84771 |
| 4 | Foot-and-mouth disease virus (subunit VP4) | protein | 46 | 26% helix, 2% strand | O90754 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1091 | 0.78 | 0.79 | 107 | empty |
| 2 | 602 | 0.71 | 0.79 | 63 | empty |
| 3 | 160 | 0.47 | 0.76 | 25 | empty |
| 4 | 89 | 0.36 | 0.76 | 19 | empty |
| 5 | 75 | 0.36 | 0.77 | 17 | empty |
Interfaces
6 interfaces between chains.
- 1–2 · 1343 Ų buried · 20 hydrogen bonds · protein-protein
- 1–3 · 989 Ų buried · 17 hydrogen bonds · protein-protein
- 2–3 · 916 Ų buried · 11 hydrogen bonds · protein-protein
- 1–4 · 779 Ų buried · 15 hydrogen bonds · protein-protein
- 2–4 · 249 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1BBT · Methods used in the structure determination of foot and mouth disease virus · the same entry in another collection · chain 2 against 2, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q84771
- Every structure of UniProt O90754
- Elsewhere: RCSB PDB 1BBT · PDBe 1BBT · UniProt Q84771 · UniProt O90754
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