MolNFT v1 · #176669 · protein
The structure of the M.TB mazf-MT9 toxin in complex with a fragment of cognate antitoxin
7DU4 · Probable endoribonuclease MAZF7: “The structure of the M.TB mazf-MT9 toxin in complex with a fragment of cognate antitoxin”. X-ray diffraction, 1 pocket (best druggability 0.46). MolNFT v1 #176669 on GenesisL1: 3D structure, binding…
- PDB
- 7DU4
- Type
- protein
- Length
- 222 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable endoribonuclease MAZF7; Peptide
- EC
- 3.1.-.-
- UniProt
- P0CL62
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Probable endoribonuclease MAZF7 (EC 3.1.-.-) | protein | 106 | 25% helix, 36% strand | P0CL62 |
| Q | Peptide | protein | 10 | 30% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 128 | 0.46 | 0.78 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1053 Ų buried · 22 hydrogen bonds · protein-protein
- A–Q · 430 Ų buried · 5 hydrogen bonds · protein-protein
- B–Q · 305 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7DU4 · The structure of the M.tb MazF-mt9 toxin in complex with a fragment of cognate antitoxin · the same entry in another collection · chain A against A, TM-score 1.00
- P0CL62 · AlphaFold monomer V2.0 prediction for probable endoribonuclease MAZF7 (P0CL62) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0CL62
- Elsewhere: RCSB PDB 7DU4 · PDBe 7DU4 · UniProt P0CL62
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