MolNFT v1 · #176629 · protein

Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide

7DSX: “Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide”. Electron microscopy, 2 ligands (PGT, HG0). MolNFT v1 #176629 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7DSX
Type: protein
Length: 1,388 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q99653, P19634
Ligands: PGT, HG0

Structure

electron microscopy · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D, C	—	protein	185	—	Q99653
B, A	—	protein	509	—	P19634

Ligands and binding sites

PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · ligand · 6 copies · chains B, A
HG0 · N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide · ligand · 2 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7DSX · Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide · the same entry in another collection · chain D against D, TM-score 1.00
P19634 · AlphaFold monomer V2.0 prediction for SODIUM/HYDROGEN exchanger 1 (P19634) · a predicted model of the same protein · chain B against A, TM-score 0.93
Q99653 · AlphaFold monomer V2.0 prediction for calcineurin B homologous protein 1 (Q99653) · a predicted model of the same protein · chain C against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99653
Every structure of UniProt P19634
Elsewhere: RCSB PDB 7DSX · PDBe 7DSX · UniProt Q99653 · UniProt P19634

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