MolNFT v1 · #176628 · protein
Structure of a human NHE1-CHP1 complex under pH 7.5
7DSW · SODIUM/HYDROGEN exchanger 1: “Structure of a human NHE1-CHP1 complex under pH 7.5”. Electron microscopy, 1 ligand (LBN), 12 pockets (best druggability 0.82). MolNFT v1 #176628 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7DSW
- Type
- protein
- Length
- 840 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SODIUM/HYDROGEN exchanger 1
- UniProt
- P19634
- Ligands
- LBN
- Pockets
- 12 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | SODIUM/HYDROGEN exchanger 1 | protein | 420 | 69% helix, 0% strand | P19634 |
Ligands and binding sites
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · ligand · 12 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1053 | 0.82 | 0.82 | 69 | LBN |
| 2 | 409 | 0.69 | 0.81 | 40 | empty |
| 3 | 415 | 0.68 | 0.80 | 37 | empty |
| 4 | 182 | 0.51 | 0.76 | 23 | empty |
| 5 | 141 | 0.48 | 0.77 | 24 | empty |
Interfaces
1 interface between chains.
- B–A · 3291 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19634
- Elsewhere: RCSB PDB 7DSW · PDBe 7DSW · UniProt P19634
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