MolNFT v1 · #176623 · protein
Anthranilate phosphoribosyltransferase variant GLY141ASN from saccharomyces cerevisiae in complex with 4-fluoroanthranilate
7DSR: “Anthranilate phosphoribosyltransferase variant GLY141ASN from saccharomyces cerevisiae in complex with…”. X-ray diffraction, 1 ligand (FA0), 6 pockets (best druggability 0.65). MolNFT v1 #176623 on GenesisL1: 3D structure, binding…
- PDB
- 7DSR
- Type
- protein
- Length
- 711 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anthranilate phosphoribosyltransferase
- EC
- 2.4.2.18
- UniProt
- P07285
- Ligands
- FA0
- Pockets
- 6 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 355 | 51% helix, 14% strand | P07285 |
| B | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 356 | 52% helix, 13% strand | P07285 |
Ligands and binding sites
- FA0 · 2-amino-4-fluorobenzoic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 387 | 0.65 | 0.79 | 45 | FA0 |
| 2 | 382 | 0.63 | 0.78 | 44 | empty |
| 3 | 74 | 0.36 | 0.76 | 17 | empty |
| 4 | 74 | 0.34 | 0.75 | 16 | empty |
| 5 | 72 | 0.32 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1238 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7DSR · Anthranilate phosphoribosyltransferase variant Gly141Asn from Saccharomyces cerevisiae in… · the same entry in another collection · chain A against A, TM-score 1.00
- P07285 · AlphaFold monomer V2.0 prediction for anthranilate phosphoribosyltransferase (P07285) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07285
- Elsewhere: RCSB PDB 7DSR · PDBe 7DSR · UniProt P07285
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