MolNFT v1 · #176618 · protein
Anthranilate phosphoribosyltransferase from saccharomyces cerevisiae
7DSM: “Anthranilate phosphoribosyltransferase from saccharomyces cerevisiae”. X-ray diffraction, 4 pockets (best druggability 0.63). MolNFT v1 #176618 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7DSM
- Type
- protein
- Length
- 708 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anthranilate phosphoribosyltransferase
- EC
- 2.4.2.18
- UniProt
- P07285
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 353 | 51% helix, 13% strand | P07285 |
| B | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 355 | 52% helix, 13% strand | P07285 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 451 | 0.63 | 0.77 | 45 | empty |
| 2 | 399 | 0.62 | 0.77 | 43 | empty |
| 3 | 72 | 0.30 | 0.73 | 20 | empty |
| 4 | 68 | 0.29 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1259 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 7DSM · Anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae · the same entry in another collection · chain A against A, TM-score 1.00
- P07285 · AlphaFold monomer V2.0 prediction for anthranilate phosphoribosyltransferase (P07285) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07285
- Elsewhere: RCSB PDB 7DSM · PDBe 7DSM · UniProt P07285
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