MolNFT v1 · #176615 · protein
Anthranilate phosphoribosyltransferase from saccharomyces cerevisiae in complex with prpp and mg
7DSJ: “Anthranilate phosphoribosyltransferase from saccharomyces cerevisiae in complex with prpp and mg”. X-ray diffraction, 2 ligands (PRP, MG), 5 pockets (best druggability 0.77). MolNFT v1 #176615 on GenesisL1: 3D structure, binding…
- PDB
- 7DSJ
- Type
- protein
- Length
- 720 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anthranilate phosphoribosyltransferase
- EC
- 2.4.2.18
- UniProt
- P07285
- Ligands
- PRP, MG
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 363 | 51% helix, 13% strand | P07285 |
| B | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 357 | 51% helix, 14% strand | P07285 |
Ligands and binding sites
- PRP · 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 498 | 0.77 | 0.85 | 51 | PRP, MG |
| 2 | 338 | 0.59 | 0.77 | 34 | PRP, MG |
| 3 | 79 | 0.34 | 0.75 | 20 | empty |
| 4 | 64 | 0.29 | 0.74 | 17 | empty |
| 5 | 60 | 0.27 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1234 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7DSJ · Anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae in complex with PRPP… · the same entry in another collection · chain A against A, TM-score 1.00
- P07285 · AlphaFold monomer V2.0 prediction for anthranilate phosphoribosyltransferase (P07285) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07285
- Elsewhere: RCSB PDB 7DSJ · PDBe 7DSJ · UniProt P07285
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