MolNFT v1 · #176605 · protein
Crystal structure of actin capping protein in complex with twinflin- 1/CD2AP cpi chimera peptide (cdn-twc)
7DS8 · F-actin-capping protein subunit alpha-1: “Crystal structure of actin capping protein in complex with twinflin- 1/CD2AP cpi chimera peptide (cdn-twc)”. X-ray diffraction, 5 pockets (best druggability 0.78). MolNFT v1 #176605 on…
- PDB
- 7DS8
- Type
- protein
- Length
- 528 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha-1; F-actin-capping protein subunit beta isoforms 1…
- UniProt
- P13127, P14315, Q9Y5K6
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 40% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-actin-capping protein subunit alpha-1 | protein | 274 | 41% helix, 33% strand | P13127 |
| B | F-actin-capping protein subunit beta isoforms 1 | protein | 242 | 40% helix, 36% strand | P14315 |
| C | CD2-associated PROTEIN,TWINFILIN-1 | protein | 12 | 33% helix, 0% strand | Q9Y5K6 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.78 | 0.97 | 19 | empty |
| 2 | 98 | 0.52 | 0.83 | 20 | empty |
| 3 | 136 | 0.44 | 0.76 | 27 | empty |
| 4 | 83 | 0.42 | 0.79 | 19 | empty |
| 5 | 86 | 0.35 | 0.75 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3712 Ų buried · 62 hydrogen bonds · protein-protein
- B–C · 803 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 109 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7DS8 · Crystal structure of actin capping protein in complex with twinflin-1/CD2AP CPI chimera… · the same entry in another collection · chain A against A, TM-score 1.00
- P14315 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit beta isoforms 1 and… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P13127 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit alpha-1 (P13127) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q9Y5K6 · AlphaFold monomer V2.0 prediction for CD2-associated protein (Q9Y5K6) · a predicted model of the same protein · chain C against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13127
- Every structure of UniProt P14315
- Every structure of UniProt Q9Y5K6
- Elsewhere: RCSB PDB 7DS8 · PDBe 7DS8 · UniProt P13127 · UniProt P14315 · UniProt Q9Y5K6
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