MolNFT v1 · #176600 · protein
Crystal structure of actin capping protein in complex with twinflin-1 C-terminus tail
7DS2 · F-actin-capping protein subunit alpha-1: “Crystal structure of actin capping protein in complex with twinflin-1 C-terminus tail”. X-ray diffraction, 6 pockets (best druggability 0.73). MolNFT v1 #176600 on GenesisL1: 3D structure…
- PDB
- 7DS2
- Type
- protein
- Length
- 530 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha-1; F-actin-capping protein subunit beta isoforms 1…
- UniProt
- P13127, P14315, Q91YR1
- Pockets
- 6 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 39% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-actin-capping protein subunit alpha-1 | protein | 272 | 40% helix, 34% strand | P13127 |
| B | F-actin-capping protein subunit beta isoforms 1 | protein | 235 | 40% helix, 37% strand | P14315 |
| C | Twinfilin-1 | protein | 23 | 0% helix, 4% strand | Q91YR1 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.73 | 0.97 | 23 | empty |
| 2 | 253 | 0.64 | 0.82 | 28 | empty |
| 3 | 138 | 0.41 | 0.75 | 19 | empty |
| 4 | 50 | 0.36 | 0.80 | 17 | empty |
| 5 | 66 | 0.35 | 0.77 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3680 Ų buried · 57 hydrogen bonds · protein-protein
- B–C · 1568 Ų buried · 29 hydrogen bonds · protein-protein
- A–C · 37 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7DS2 · Crystal structure of actin capping protein in complex with twinflin-1 C-terminus tail · the same entry in another collection · chain A against A, TM-score 1.00
- P14315 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit beta isoforms 1 and… · a predicted model of the same protein · chain B against A, TM-score 0.97
- P13127 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit alpha-1 (P13127) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q91YR1 · AlphaFold monomer V2.0 prediction for twinfilin-1 (Q91YR1) · a predicted model of the same protein · chain C against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13127
- Every structure of UniProt P14315
- Every structure of UniProt Q91YR1
- Elsewhere: RCSB PDB 7DS2 · PDBe 7DS2 · UniProt P13127 · UniProt P14315 · UniProt Q91YR1
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