MolNFT v1 · #176514 · protein + DNA
RNA methyltransferase METTL4
7DPE · DNA (5'- D(*GP*CP*CP*GP*CP*GP*TP*GP*AP*TP*CP*AP*CP*GP*CP*GP*…: “RNA methyltransferase METTL4”. X-ray diffraction, 1 ligand (SAH), 3 pockets (best druggability 0.80). MolNFT v1 #176514 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7DPE
- Type
- protein + DNA
- Length
- 354 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*GP*CP*CP*GP*CP*GP*TP*GP*AP*TP*CP*AP*CP*GP*CP*GP*GP*C)-3')…
- EC
- 2.1.1.-
- UniProt
- Q8LFA9
- Ligands
- SAH
- Pockets
- 3 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | DNA (5'- D(*GP*CP*CP*GP*CP*GP*TP*GP*AP*TP*CP*AP*CP*GP*CP*GP*GP*C)-3') | dna | 18 | — | — |
| A | Methyltransferase-like protein 2 (EC 2.1.1.-) | protein | 336 | 26% helix, 26% strand | Q8LFA9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 923 | 0.80 | 0.82 | 102 | SAH, GOL |
| 2 | 94 | 0.38 | 0.75 | 19 | empty |
| 3 | 65 | 0.34 | 0.77 | 16 | GOL |
Interfaces
1 interface between chains.
- B–A · 353 Ų buried · 3 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8LFA9
- Elsewhere: RCSB PDB 7DPE · PDBe 7DPE · UniProt Q8LFA9
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