MolNFT v1 · #176513 · protein
Human MCM9 N-terminal domain
7DPD · DNA helicase MCM9: “Human MCM9 N-terminal domain”. X-ray diffraction, 2 ligands (ZN, NA), 4 pockets (best druggability 0.66). MolNFT v1 #176513 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7DPD
- Type
- protein
- Length
- 545 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA helicase MCM9
- EC
- 3.6.4.12
- UniProt
- Q9NXL9
- Ligands
- ZN, NA
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA helicase MCM9 (EC 3.6.4.12) | protein | 272 | 28% helix, 32% strand | Q9NXL9 |
| B | DNA helicase MCM9 (EC 3.6.4.12) | protein | 273 | 29% helix, 33% strand | Q9NXL9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 371 | 0.66 | 0.80 | 38 | empty |
| 2 | 327 | 0.63 | 0.80 | 33 | empty |
| 3 | 124 | 0.43 | 0.77 | 26 | empty |
| 4 | 52 | 0.32 | 0.78 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 385 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NXL9
- Elsewhere: RCSB PDB 7DPD · PDBe 7DPD · UniProt Q9NXL9
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