UniProt Q9NXL9
DNA helicase MCM9 (Q9NXL9)
DNA helicase MCM9 (UniProt Q9NXL9), EC 3.6.4.12: 7 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 87 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NXL9
- Protein
- DNA helicase MCM9
- EC
- 3.6.4.12
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 87 · 7 records with a druggable one
Structures
8 records of Q9NXL9 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7DPD | Human MCM9 N-terminal domain | x-ray diffraction | A, B | ZN, NA | 4 (best 0.66) |
| 7DPD | Human MCM9 N-terminal domain | x-ray diffraction | A, B | ZN, NA | — |
| 7WI7 | Crystal structure of human MCM8/9 complex | x-ray diffraction | B | ZN | 11 (best 0.81) |
| 7YOX | Cryo-EM structure of the N-terminal domain of hMCM8/9 and HROB | electron microscopy | B, D, E | — | 18 (best 0.78) |
| 8S91 | Structure of Walker B mutated MCM8/9 heterohexamer complex with ADP | electron microscopy | D, E, F | ADP, MG | 17 (best 0.85) |
| 8S92 | Structure of N-terminal domains of Walker B mutated MCM8/9 heterohexamer complex with ADP | electron microscopy | D, E, F | — | 13 (best 0.74) |
| 8S94 | Structure of C-terminal domains of Walker B mutated MCM8/9 heterohexamer complex with ADP | electron microscopy | D, F, E | ADP, MG | 15 (best 0.85) |
| Q9NXL9 | AlphaFold monomer V2.0 prediction for DNA helicase MCM9 (Q9NXL9) | predicted | A | — | 9 (best 0.70) |
Ligands
Experiment against prediction
- 8S94 chain E against the predicted model Q9NXL9: TM-score 0.96, RMSD 1.55 Å
- 8S94 chain F against the predicted model Q9NXL9: TM-score 0.96, RMSD 1.57 Å
- 8S94 chain D against the predicted model Q9NXL9: TM-score 0.96, RMSD 1.58 Å
- 8S92 chain E against the predicted model Q9NXL9: TM-score 0.95, RMSD 1.33 Å
- 8S92 chain D against the predicted model Q9NXL9: TM-score 0.95, RMSD 1.33 Å
- 8S92 chain F against the predicted model Q9NXL9: TM-score 0.95, RMSD 1.34 Å
- 7DPD chain A against the predicted model Q9NXL9: TM-score 0.93, RMSD 1.84 Å
- 7DPD chain A against the predicted model Q9NXL9: TM-score 0.93, RMSD 1.84 Å
- 7DPD chain B against the predicted model Q9NXL9: TM-score 0.93, RMSD 1.87 Å
- 7DPD chain B against the predicted model Q9NXL9: TM-score 0.93, RMSD 1.87 Å
Elsewhere
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