MolNFT v1 · #176471 · protein
Crystal structure of zn-bound sis domain of glucosamine-6-P synthase from E. COLI
7DNR · Glutamine--fructose-6-phosphate aminotransferase…: “Crystal structure of zn-bound sis domain of glucosamine-6-P synthase from E. COLI”. X-ray diffraction, 1 ligand (ZN), 6 pockets (best druggability 0.88). MolNFT v1 #176471 on…
- PDB
- 7DNR
- Type
- protein
- Length
- 711 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
- EC
- 2.6.1.16
- UniProt
- P17169
- Ligands
- ZN
- Pockets
- 6 · best druggability 0.88
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) | protein | 357 | 48% helix, 18% strand | P17169 |
| B | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) | protein | 354 | 50% helix, 18% strand | P17169 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 880 | 0.88 | 0.90 | 67 | empty |
| 2 | 141 | 0.53 | 0.80 | 18 | empty |
| 3 | 172 | 0.50 | 0.78 | 22 | empty |
| 4 | 127 | 0.50 | 0.80 | 17 | empty |
| 5 | 160 | 0.43 | 0.75 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 2050 Ų buried · 38 hydrogen bonds · protein-protein
Compared structures
- 7DNR · Crystal Structure of Zn-bound SIS Domain of Glucosamine-6-P Synthase from E. coli · the same entry in another collection · chain A against A, TM-score 1.00
- P17169 · AlphaFold monomer V2.0 prediction for glutamine--fructose-6-phosphate aminotransferase… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17169
- Elsewhere: RCSB PDB 7DNR · PDBe 7DNR · UniProt P17169
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