MolNFT v1 · #17640 · protein
Crystal structure of the mutated tRNA-guanine transglycosylase (tgt) Y106F complexed with PREQ1
1OZQ · Queuine tRNA-ribosyltransferase: “Crystal structure of the mutated tRNA-guanine transglycosylase (tgt) Y106F complexed with PREQ1”. X-ray diffraction, 2 ligands (PRF, ZN), 3 pockets (best druggability 0.63). MolNFT v1 #17640 on…
- PDB
- 1OZQ
- Type
- protein
- Length
- 372 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Queuine tRNA-ribosyltransferase
- EC
- 2.4.2.29
- UniProt
- P28720
- Ligands
- PRF, ZN
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Queuine tRNA-ribosyltransferase (EC 2.4.2.29) | protein | 372 | 47% helix, 19% strand | P28720 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 268 | 0.63 | 0.81 | 39 | PRF |
| 2 | 62 | 0.42 | 0.81 | 21 | empty |
| 3 | 78 | 0.37 | 0.77 | 17 | empty |
Compared structures
- 1OZQ · Crystal structure of the mutated tRNA-guanine transglycosylase (TGT)Y106F complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28720
- Elsewhere: RCSB PDB 1OZQ · PDBe 1OZQ · UniProt P28720
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