MolNFT v1 · #176143 · protein
The structure of the arabidopsis thaliana guanosine deaminase complexed with adenosine
7DCW: “The structure of the arabidopsis thaliana guanosine deaminase complexed with adenosine”. X-ray diffraction, 2 ligands (ADN, ZN), 3 pockets (best druggability 0.76). MolNFT v1 #176143 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7DCW
- Type
- protein
- Length
- 314 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanosine deaminase
- EC
- 3.5.4.15
- UniProt
- Q94BU8
- Ligands
- ADN, ZN
- Pockets
- 3 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Guanosine deaminase (EC 3.5.4.15) | protein | 157 | 42% helix, 19% strand | Q94BU8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 128 | 0.76 | 0.94 | 25 | ADN |
| 2 | 155 | 0.74 | 0.91 | 26 | ADN |
| 3 | 61 | 0.27 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–D · 1567 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7DCW · The structure of the Arabidopsis thaliana guanosine deaminase complexed with adenosine · the same entry in another collection · chain A against A, TM-score 1.00
- Q94BU8 · AlphaFold monomer V2.0 prediction for guanosine deaminase (Q94BU8) · a predicted model of the same protein · chain D against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94BU8
- Elsewhere: RCSB PDB 7DCW · PDBe 7DCW · UniProt Q94BU8
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