MolNFT v1 · #17587 · protein
Coupling of folding and binding in the ptb domain of the signaling protein shc
1OY2 · Shc transforming protein: “Coupling of folding and binding in the ptb domain of the signaling protein shc”. Solution nmr, 3 pockets (best druggability 0.69). MolNFT v1 #17587 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1OY2
- Type
- protein
- Length
- 191 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Shc transforming protein
- UniProt
- P29353
- Pockets
- 3 · best druggability 0.69
Structure
solution nmr · 1 distinct chain · 14% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Shc transforming protein | protein | 191 | 14% helix, 20% strand | P29353 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 334 | 0.69 | 0.82 | 46 | empty |
| 2 | 121 | 0.63 | 0.87 | 26 | empty |
| 3 | 57 | 0.30 | 0.76 | 14 | empty |
Compared structures
- 1OY2 · Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc · the same entry in another collection · chain A against A, TM-score 1.00
- P29353 · AlphaFold monomer V2.0 prediction for shc-transforming protein 1 (P29353) · a predicted model of the same protein · chain A against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29353
- Elsewhere: RCSB PDB 1OY2 · PDBe 1OY2 · UniProt P29353
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