MolNFT v1 · #175618 · protein
Structural basis of RACK7 phd to read a pediatric glioblastoma- associated histone mutation H3.3G34R
7CWH · Peptide from histone H3.3: “Structural basis of RACK7 phd to read a pediatric glioblastoma- associated histone mutation H3.3G34R”. Solution nmr, 1 ligand (ZN), 1 pocket (best druggability 0.35). MolNFT v1 #175618 on GenesisL1: 3D…
- PDB
- 7CWH
- Type
- protein
- Length
- 72 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptide from histone H3.3; Protein kinase C-binding protein 1
- UniProt
- P84243, Q5TH12
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.35
Structure
solution nmr · 2 distinct chains · 13% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptide from histone H3.3 | protein | 11 | 0% helix, 0% strand | P84243 |
| B | Protein kinase C-binding protein 1 | protein | 61 | 15% helix, 13% strand | Q5TH12 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.35 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 437 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7CWH · Structural basis of RACK7 PHD to read a pediatric glioblastoma-associated histone… · the same entry in another collection · chain A against A, TM-score 1.00
- P84243 · AlphaFold monomer V2.0 prediction for histone H3.3 (P84243) · a predicted model of the same protein · chain A against A, TM-score 0.28
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84243
- Every structure of UniProt Q5TH12
- Elsewhere: RCSB PDB 7CWH · PDBe 7CWH · UniProt P84243 · UniProt Q5TH12
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