MolNFT v1 · #175583 · protein

RNA methyltransferase METTL4

7CV7 · Methyltransferase-like protein 2: “RNA methyltransferase METTL4”. X-ray diffraction, 1 ligand (SAM), 11 pockets (best druggability 0.86). MolNFT v1 #175583 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7CV7
Type: protein
Length: 703 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methyltransferase-like protein 2
EC: 2.1.1.-
UniProt: Q8LFA9
Ligands: SAM
Pockets: 11 · best druggability 0.86

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methyltransferase-like protein 2 (EC 2.1.1.-)	protein	353	30% helix, 25% strand	Q8LFA9
B	Methyltransferase-like protein 2 (EC 2.1.1.-)	protein	350	30% helix, 26% strand	Q8LFA9

Ligands and binding sites

SAM · S-adenosylmethionine · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	981	0.86	0.87	111	SAM
2	322	0.75	0.86	46	SAM
3	186	0.55	0.79	31	empty
4	114	0.52	0.82	20	empty
5	140	0.45	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 1602 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

7CV7 · RNA methyltransferase METTL4 · the same entry in another collection · chain A against A, TM-score 1.00
Q8LFA9 · AlphaFold monomer V2.0 prediction for methyltransferase-like protein 2 (Q8LFA9) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8LFA9
Elsewhere: RCSB PDB 7CV7 · PDBe 7CV7 · UniProt Q8LFA9

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.