MolNFT v1 · #175582 · protein
RNA methyltransferase METTL4
7CV6 · Methyltransferase-like protein 2: “RNA methyltransferase METTL4”. X-ray diffraction, 2 ligands (A2M, SAH), 4 pockets (best druggability 0.76). MolNFT v1 #175582 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7CV6
- Type
- protein
- Length
- 347 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methyltransferase-like protein 2
- EC
- 2.1.1.-
- UniProt
- Q8LFA9
- Ligands
- A2M, SAH
- Pockets
- 4 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Methyltransferase-like protein 2 (EC 2.1.1.-) | protein | 347 | 25% helix, 25% strand | Q8LFA9 |
Ligands and binding sites
- A2M · 2'-O-methyladenosine 5'-(dihydrogen phosphate) · ligand · 2 copies · chains B
- SAH · S-adenosyl-L-homocysteine · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 500 | 0.76 | 0.83 | 86 | SAH |
| 2 | 471 | 0.62 | 0.76 | 49 | A2M |
| 3 | 75 | 0.34 | 0.76 | 16 | empty |
| 4 | 86 | 0.34 | 0.74 | 22 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8LFA9
- Elsewhere: RCSB PDB 7CV6 · PDBe 7CV6 · UniProt Q8LFA9
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