MolNFT v1 · #175578 · protein
Structure of human trnahis guanylyltransferase (THG1) in the presence of human mitochondrial trnahis
7CV1 · Probable TRNA(HIS) guanylyltransferase: “Structure of human trnahis guanylyltransferase (THG1) in the presence of human mitochondrial trnahis”. X-ray diffraction, 10 pockets (best druggability 0.83). MolNFT v1 #175578 on GenesisL1…
- PDB
- 7CV1
- Type
- protein
- Length
- 986 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable TRNA(HIS) guanylyltransferase
- EC
- 2.7.7.79
- UniProt
- Q9NWX6
- Pockets
- 10 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable TRNA(HIS) guanylyltransferase (EC 2.7.7.79) | protein | 251 | 49% helix, 21% strand | Q9NWX6 |
| B | Probable TRNA(HIS) guanylyltransferase (EC 2.7.7.79) | protein | 241 | 49% helix, 17% strand | Q9NWX6 |
| C | Probable TRNA(HIS) guanylyltransferase (EC 2.7.7.79) | protein | 246 | 50% helix, 18% strand | Q9NWX6 |
| D | Probable TRNA(HIS) guanylyltransferase (EC 2.7.7.79) | protein | 248 | 49% helix, 19% strand | Q9NWX6 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1193 | 0.83 | 0.84 | 76 | empty |
| 2 | 286 | 0.65 | 0.82 | 33 | empty |
| 3 | 278 | 0.64 | 0.81 | 29 | empty |
| 4 | 292 | 0.63 | 0.80 | 31 | empty |
| 5 | 259 | 0.62 | 0.81 | 33 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2076 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 2073 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 283 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 279 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 245 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7CV1 · Structure of human tRNAHis guanylyltransferase (Thg1) in the presence of human… · the same entry in another collection · chain D against D, TM-score 1.00
- Q9NWX6 · AlphaFold monomer V2.0 prediction for probable TRNA(HIS) guanylyltransferase (Q9NWX6) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWX6
- Elsewhere: RCSB PDB 7CV1 · PDBe 7CV1 · UniProt Q9NWX6
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