Research workbench
Structure of human trnahis guanylyltransferase (THG1) in the presence of human mitochondrial trnahis
Analyse Structure of human trnahis guanylyltransferase (THG1) in the presence of human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7CV1
- Type
- protein
- Length
- 986 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable TRNA(HIS) guanylyltransferase
- EC
- 2.7.7.79
- UniProt
- Q9NWX6
- Pockets
- 10 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable TRNA(HIS) guanylyltransferase (EC 2.7.7.79) | protein | 251 | 49% helix, 21% strand | Q9NWX6 |
| B | Probable TRNA(HIS) guanylyltransferase (EC 2.7.7.79) | protein | 241 | 49% helix, 17% strand | Q9NWX6 |
| C | Probable TRNA(HIS) guanylyltransferase (EC 2.7.7.79) | protein | 246 | 50% helix, 18% strand | Q9NWX6 |
| D | Probable TRNA(HIS) guanylyltransferase (EC 2.7.7.79) | protein | 248 | 49% helix, 19% strand | Q9NWX6 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1193 | 0.83 | 0.84 | 76 | empty |
| 2 | 286 | 0.65 | 0.82 | 33 | empty |
| 3 | 278 | 0.64 | 0.81 | 29 | empty |
| 4 | 292 | 0.63 | 0.80 | 31 | empty |
| 5 | 259 | 0.62 | 0.81 | 33 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2076 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 2073 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 283 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 279 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 245 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7CV1 · Structure of human tRNAHis guanylyltransferase (Thg1) in the presence of human… · the same entry in another collection · chain D against D, TM-score 1.00
- Q9NWX6 · AlphaFold monomer V2.0 prediction for probable TRNA(HIS) guanylyltransferase (Q9NWX6) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWX6
- Elsewhere: RCSB PDB 7CV1 · PDBe 7CV1 · UniProt Q9NWX6
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