MolNFT v1 · #175552 · protein
Crystal structure of the soluble domain of time protein from mycobacterium smegmatis
7CU9 · Tube-forming protein in mycobacterial envelpe, time: “Crystal structure of the soluble domain of time protein from mycobacterium smegmatis”. X-ray diffraction, 1 ligand (MG), 4 pockets (best druggability 0.53). MolNFT v1 #175552 on…
- PDB
- 7CU9
- Type
- protein
- Length
- 384 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tube-forming protein in mycobacterial envelpe, time
- UniProt
- A0R5N2
- Ligands
- MG
- Pockets
- 4 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tube-forming protein in mycobacterial envelpe, time | protein | 191 | 27% helix, 38% strand | A0R5N2 |
| B | Tube-forming protein in mycobacterial envelpe, time | protein | 193 | 26% helix, 37% strand | A0R5N2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 193 | 0.53 | 0.78 | 23 | empty |
| 2 | 188 | 0.51 | 0.77 | 24 | empty |
| 3 | 78 | 0.42 | 0.80 | 22 | GOL |
| 4 | 74 | 0.36 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 491 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7CU9 · Crystal structure of the soluble domain of TiME protein from Mycobacterium smegmatis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0R5N2
- Elsewhere: RCSB PDB 7CU9 · PDBe 7CU9 · UniProt A0R5N2
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