Research workbench
Crystal structure of the soluble domain of time protein from mycobacterium smegmatis
Analyse Crystal structure of the soluble domain of time protein from mycobacterium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7CU9
- Type
- protein
- Length
- 384 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tube-forming protein in mycobacterial envelpe, time
- UniProt
- A0R5N2
- Ligands
- MG
- Pockets
- 4 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tube-forming protein in mycobacterial envelpe, time | protein | 191 | 27% helix, 38% strand | A0R5N2 |
| B | Tube-forming protein in mycobacterial envelpe, time | protein | 193 | 26% helix, 37% strand | A0R5N2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 193 | 0.53 | 0.78 | 23 | empty |
| 2 | 188 | 0.51 | 0.77 | 24 | empty |
| 3 | 78 | 0.42 | 0.80 | 22 | GOL |
| 4 | 74 | 0.36 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 491 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7CU9 · Crystal structure of the soluble domain of TiME protein from Mycobacterium smegmatis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0R5N2
- Elsewhere: RCSB PDB 7CU9 · PDBe 7CU9 · UniProt A0R5N2
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