MolNFT v1 · #175475 · protein
Hnrnpk nls in complex with importin alpha 1 (KPNA2)
7CRU · Heterogeneous nuclear ribonucleoprotein K: “Hnrnpk nls in complex with importin alpha 1 (KPNA2)”. X-ray diffraction, 5 pockets (best druggability 0.45). MolNFT v1 #175475 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7CRU
- Type
- protein
- Length
- 893 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heterogeneous nuclear ribonucleoprotein K; Importin subunit alpha-1
- UniProt
- P61978, P52292
- Pockets
- 5 · best druggability 0.45
Structure
x-ray diffraction · 3 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, D | Heterogeneous nuclear ribonucleoprotein K | protein | 20 | 0% helix, 0% strand | P61978 |
| A | Importin subunit alpha-1 | protein | 428 | 74% helix, 0% strand | P52292 |
| C | Importin subunit alpha-1 | protein | 425 | 74% helix, 0% strand | P52292 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 95 | 0.45 | 0.80 | 15 | empty |
| 2 | 75 | 0.39 | 0.78 | 17 | empty |
| 3 | 85 | 0.32 | 0.73 | 20 | ACT |
| 4 | 60 | 0.27 | 0.73 | 16 | empty |
| 5 | 50 | 0.24 | 0.72 | 15 | empty |
Interfaces
2 interfaces between chains.
- B–A · 1552 Ų buried · 32 hydrogen bonds · protein-protein
- D–C · 1540 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 7CRU · hnRNPK NLS in complex with Importin alpha 1 (KPNA2) · the same entry in another collection · chain C against C, TM-score 1.00
- P52292 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52292) · a predicted model of the same protein · chain C against A, TM-score 0.99
- P61978 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein K (P61978) · a predicted model of the same protein · chain B against A, TM-score 0.17
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61978
- Every structure of UniProt P52292
- Elsewhere: RCSB PDB 7CRU · PDBe 7CRU · UniProt P61978 · UniProt P52292
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