MolNFT v1 · #175412 · protein
Lovastatin nonaketide synthase with lovc
7CPY · Lovastatin nonaketide synthase, enoyl reductase component…: “Lovastatin nonaketide synthase with lovc”. Electron microscopy, 1 ligand (NAP), 20 pockets (best druggability 0.79). MolNFT v1 #175412 on GenesisL1: 3D structure, binding…
- PDB
- 7CPY
- Type
- protein
- Length
- 5,238 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lovastatin nonaketide synthase, enoyl reductase component lovc; Lovastatin nonaketide…
- EC
- 2.3.1.161
- UniProt
- Q9Y7D0, Q9Y8A5
- Ligands
- NAP
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 2 distinct chains · 36% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, D | Lovastatin nonaketide synthase, enoyl reductase component lovc (EC 2.3.1.161) | protein | 357 | 28% helix, 25% strand | Q9Y7D0 |
| A, B | Lovastatin nonaketide synthase, polyketide synthase component (EC 2.3.1.161) | protein | 2262 | 37% helix, 21% strand | Q9Y8A5 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 767 | 0.79 | 0.82 | 70 | empty |
| 2 | 780 | 0.79 | 0.82 | 75 | empty |
| 3 | 804 | 0.77 | 0.81 | 76 | empty |
| 4 | 372 | 0.76 | 0.86 | 49 | NAP |
| 5 | 780 | 0.76 | 0.80 | 93 | empty |
Interfaces
1 interface between chains.
- A–B · 6661 Ų buried · 106 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y7D0
- Every structure of UniProt Q9Y8A5
- Elsewhere: RCSB PDB 7CPY · PDBe 7CPY · UniProt Q9Y7D0 · UniProt Q9Y8A5
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