MolNFT v1 · #175101 · protein
Crystal structure of human unphosphorylated P38GAMMA
7CGA · Mitogen-activated protein kinase 12: “Crystal structure of human unphosphorylated P38GAMMA”. X-ray diffraction, 20 pockets (best druggability 0.87). MolNFT v1 #175101 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7CGA
- Type
- protein
- Length
- 1,388 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 12
- EC
- 2.7.11.24
- UniProt
- P53778
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Mitogen-activated protein kinase 12 (EC 2.7.11.24) | protein | 347 | 37% helix, 17% strand | P53778 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1126 | 0.87 | 0.88 | 126 | empty |
| 2 | 199 | 0.75 | 0.90 | 35 | empty |
| 3 | 323 | 0.67 | 0.82 | 37 | empty |
| 4 | 275 | 0.67 | 0.83 | 42 | empty |
| 5 | 290 | 0.65 | 0.81 | 36 | empty |
Interfaces
3 interfaces between chains.
- B–C · 2129 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 610 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 489 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53778
- Elsewhere: RCSB PDB 7CGA · PDBe 7CGA · UniProt P53778
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