MolNFT v1 · #175082 · protein
Crystal structure of WDR5 in complex with H3K4ME3Q5SER peptide
7CFQ · Wd repeat-containing protein 5: “Crystal structure of WDR5 in complex with H3K4ME3Q5SER peptide”. X-ray diffraction, 1 ligand (SRO), 1 pocket (best druggability 0.75). MolNFT v1 #175082 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7CFQ
- Type
- protein
- Length
- 311 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing protein 5; H3K4ME3Q5SER peptide
- UniProt
- P61964
- Ligands
- SRO
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Wd repeat-containing protein 5 | protein | 304 | 0% helix, 52% strand | P61964 |
| B | H3K4ME3Q5SER peptide | protein | 7 | 0% helix, 0% strand | — |
Ligands and binding sites
- SRO · Serotonin · ligand · chains A, B
- GOL · Glycerol · additive · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 498 | 0.75 | 0.83 | 45 | EDO |
Interfaces
1 interface between chains.
- A–B · 545 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 7CFQ · Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61964
- Elsewhere: RCSB PDB 7CFQ · PDBe 7CFQ · UniProt P61964
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