MolNFT v1 · #17484 · protein + DNA
Crystal structure of a mutant ihf (BETAE44A) complexed with a variant H' site (T44A)
1OUZ · Phage lambda H' site: “Crystal structure of a mutant ihf (BETAE44A) complexed with a variant H' site (T44A)”. X-ray diffraction, 6 pockets (best druggability 0.80). MolNFT v1 #17484 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1OUZ
- Type
- protein + DNA
- Length
- 260 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phage lambda H' site; 5'-D(*GP*GP*CP*CP*AP*AP*AP*AP*AP*AP*GP*CP*AP*TP*T)-3'…
- UniProt
- P0A6X7, P0A6Y1
- Pockets
- 6 · best druggability 0.80
Structure
x-ray diffraction · 5 distinct chains · 39% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Phage lambda H' site | dna | 35 | — | — |
| D | 5'-D(*GP*GP*CP*CP*AP*AP*AP*AP*AP*AP*GP*CP*AP*TP*T)-3' | dna | 15 | — | — |
| E | 5'-D(*GP*CP*TP*TP*AP*TP*CP*AP*AP*TP*TP*TP*GP*TP*AP*GP*CP*AP *CP*C)-3' | dna | 20 | — | — |
| A | Integration host factor alpha-subunit | protein | 96 | 38% helix, 29% strand | P0A6X7 |
| B | Integration host factor beta-subunit | protein | 94 | 40% helix, 30% strand | P0A6Y1 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 826 | 0.80 | 0.84 | 73 | empty |
| 2 | 319 | 0.64 | 0.80 | 25 | empty |
| 3 | 153 | 0.55 | 0.82 | 29 | empty |
| 4 | 214 | 0.49 | 0.75 | 19 | empty |
| 5 | 236 | 0.47 | 0.74 | 19 | empty |
Interfaces
10 interfaces between chains.
- A–B · 2471 Ų buried · 29 hydrogen bonds · protein-protein
- C–E · 924 Ų buried · 72 hydrogen bonds · nucleic-nucleic
- C–B · 817 Ų buried · 20 hydrogen bonds · protein-nucleic
- C–A · 685 Ų buried · 9 hydrogen bonds · protein-nucleic
- C–D · 683 Ų buried · 48 hydrogen bonds · nucleic-nucleic
Compared structures
- 1OUZ · Crystal structure of a mutant IHF (BetaE44A) complexed with a variant H' Site (T44A) · the same entry in another collection · chain D against D, TM-score 1.00
- P0A6Y1 · AlphaFold monomer V2.0 prediction for integration host factor subunit beta (P0A6Y1) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P0A6X7 · AlphaFold monomer V2.0 prediction for integration host factor subunit alpha (P0A6X7) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6X7
- Every structure of UniProt P0A6Y1
- Elsewhere: RCSB PDB 1OUZ · PDBe 1OUZ · UniProt P0A6X7 · UniProt P0A6Y1
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