MolNFT v1 · #174513 · protein
Clc-7/OSTM1 membrane protein complex
7BXU · Osteopetrosis-associated transmembrane protein 1: “Clc-7/OSTM1 membrane protein complex”. Electron microscopy, 1 ligand (NAG), 20 pockets (best druggability 0.82). MolNFT v1 #174513 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7BXU
- Type
- protein
- Length
- 1,752 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Osteopetrosis-associated transmembrane protein 1; H(+)/CL(-) exchange transporter 7
- UniProt
- Q86WC4, P51798
- Ligands
- NAG
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 52% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, D | Osteopetrosis-associated transmembrane protein 1 | protein | 203 | 64% helix, 0% strand | Q86WC4 |
| A, B | H(+)/CL(-) exchange transporter 7 | protein | 673 | 49% helix, 4% strand | P51798 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 14 copies · chains C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 579 | 0.82 | 0.88 | 64 | empty |
| 2 | 930 | 0.82 | 0.83 | 69 | empty |
| 3 | 560 | 0.80 | 0.86 | 54 | empty |
| 4 | 769 | 0.80 | 0.83 | 53 | empty |
| 5 | 424 | 0.76 | 0.85 | 48 | empty |
Interfaces
4 interfaces between chains.
- A–B · 3704 Ų buried · 30 hydrogen bonds · protein-protein
- C–D · 1997 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 1088 Ų buried · 7 hydrogen bonds · protein-protein
- C–B · 1074 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 glycan, 6 disulfide (N-glycosylation, disulfide).
Compared structures
- 7BXU · CLC-7/Ostm1 membrane protein complex · the same entry in another collection · chain C against C, TM-score 1.00
- P51798 · AlphaFold monomer V2.0 prediction for H(+)/CL(-) exchange transporter 7 (P51798) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q86WC4 · AlphaFold monomer V2.0 prediction for osteopetrosis-associated transmembrane protein 1… · a predicted model of the same protein · chain C against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86WC4
- Every structure of UniProt P51798
- Elsewhere: RCSB PDB 7BXU · PDBe 7BXU · UniProt Q86WC4 · UniProt P51798
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