MolNFT v1 · #174321 · protein
Crystal structure of SEC62 lir fused to gabarap
7BRT · Translocation protein SEC62,GAMMA-aminobutyric acid…: “Crystal structure of SEC62 lir fused to gabarap”. X-ray diffraction, 2 pockets (best druggability 0.61). MolNFT v1 #174321 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7BRT
- Type
- protein
- Length
- 268 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translocation protein SEC62,GAMMA-aminobutyric acid receptor-associated protein
- UniProt
- Q99442, O95166
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Translocation protein SEC62,GAMMA-aminobutyric acid receptor-associated protein | protein | 134 | 35% helix, 19% strand | Q99442, O95166 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 541 | 0.61 | 0.74 | 50 | empty |
| 2 | 53 | 0.26 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 777 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7BRT · Crystal structure of Sec62 LIR fused to GABARAP · the same entry in another collection · chain A against A, TM-score 1.00
- O95166 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated protein… · a predicted model of the same protein · chain B against A, TM-score 0.85
- Q99442 · AlphaFold monomer V2.0 prediction for translocation protein SEC62 (Q99442) · a predicted model of the same protein · chain A against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99442
- Every structure of UniProt O95166
- Elsewhere: RCSB PDB 7BRT · PDBe 7BRT · UniProt Q99442 · UniProt O95166
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