MolNFT v1 · #17407 · protein
Structure of 3-isopropylmalate dehydrogenase
1OSJ: “Structure of 3-isopropylmalate dehydrogenase”. X-ray diffraction, 5 pockets (best druggability 0.68). MolNFT v1 #17407 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1OSJ
- Type
- protein
- Length
- 690 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3-isopropylmalate dehydrogenase
- EC
- 1.1.1.85
- UniProt
- Q5SIY4
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 3-isopropylmalate dehydrogenase (EC 1.1.1.85) | protein | 345 | 48% helix, 21% strand | Q5SIY4 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 226 | 0.68 | 0.85 | 42 | empty |
| 2 | 594 | 0.67 | 0.77 | 41 | empty |
| 3 | 138 | 0.66 | 0.88 | 24 | empty |
| 4 | 563 | 0.64 | 0.76 | 48 | empty |
| 5 | 62 | 0.32 | 0.76 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 2198 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SIY4
- Elsewhere: RCSB PDB 1OSJ · PDBe 1OSJ · UniProt Q5SIY4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.