MolNFT v1 · #17406 · protein
Structure of 3-isopropylmalate dehydrogenase
1OSI: “Structure of 3-isopropylmalate dehydrogenase”. X-ray diffraction, 18 pockets (best druggability 0.69). MolNFT v1 #17406 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1OSI
- Type
- protein
- Length
- 1,380 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3-isopropylmalate dehydrogenase
- EC
- 1.1.1.85
- UniProt
- Q5SIY4
- Pockets
- 18 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | 3-isopropylmalate dehydrogenase (EC 1.1.1.85) | protein | 345 | 47% helix, 19% strand | Q5SIY4 |
Pockets
18 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 96 | 0.69 | 0.92 | 22 | empty |
| 2 | 128 | 0.69 | 0.90 | 24 | empty |
| 3 | 101 | 0.65 | 0.90 | 20 | empty |
| 4 | 523 | 0.65 | 0.77 | 40 | empty |
| 5 | 87 | 0.64 | 0.90 | 22 | empty |
Interfaces
5 interfaces between chains.
- A–C · 2119 Ų buried · 37 hydrogen bonds · protein-protein
- B–D · 2110 Ų buried · 37 hydrogen bonds · protein-protein
- C–D · 118 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 75 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 41 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SIY4
- Elsewhere: RCSB PDB 1OSI · PDBe 1OSI · UniProt Q5SIY4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.