MolNFT v1 · #173954 · protein + DNA + RNA
The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate
7BG9 · Telomerase reverse TRANSCRIPTASE,TELOMERASE reverse…: “The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #173954 on GenesisL1…
- PDB
- 7BG9
- Type
- protein + DNA + RNA
- Length
- 1,347 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase reverse TRANSCRIPTASE,TELOMERASE reverse transcriptase; DNA…
- EC
- 2.7.7.49
- UniProt
- O14746, B4DR52, B2R5B3
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 5 distinct chains · 47% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomerase reverse TRANSCRIPTASE,TELOMERASE reverse transcriptase (EC 2.7.7.49) | protein | 913 | 42% helix, 11% strand | O14746 |
| N | DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3') | dna | 6 | — | — |
| M | Histone H2B | protein | 90 | 77% helix, 3% strand | B4DR52 |
| L | Histone H2A | protein | 82 | 63% helix, 4% strand | B2R5B3 |
| B | RNA (256-mer) | rna | 256 | — | — |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 937 | 0.83 | 0.84 | 82 | empty |
| 2 | 1058 | 0.80 | 0.82 | 92 | empty |
| 3 | 1140 | 0.78 | 0.81 | 81 | empty |
| 4 | 142 | 0.77 | 0.94 | 35 | empty |
| 5 | 1034 | 0.76 | 0.79 | 58 | empty |
Interfaces
6 interfaces between chains.
- A–B · 5772 Ų buried · 91 hydrogen bonds · protein-nucleic
- M–L · 2506 Ų buried · 15 hydrogen bonds · protein-protein
- A–N · 659 Ų buried · 10 hydrogen bonds · protein-nucleic
- L–B · 498 Ų buried · 8 hydrogen bonds · protein-nucleic
- M–B · 495 Ų buried · 5 hydrogen bonds · protein-nucleic
Compared structures
- 7BG9 · The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate · the same entry in another collection · chain A against A, TM-score 1.00
- O14746 · AlphaFold monomer V2.0 prediction for telomerase reverse transcriptase (O14746) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14746
- Every structure of UniProt B4DR52
- Every structure of UniProt B2R5B3
- Elsewhere: RCSB PDB 7BG9 · PDBe 7BG9 · UniProt O14746 · UniProt B4DR52 · UniProt B2R5B3
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