MolNFT v1 · #173896 · protein
X-ray structure of WDR5 bound to the WDR5 win motif peptide
7BED · Wd repeat-containing protein 5: “X-ray structure of WDR5 bound to the WDR5 win motif peptide”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.73). MolNFT v1 #173896 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7BED
- Type
- protein
- Length
- 317 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing protein 5
- UniProt
- P61964
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Wd repeat-containing protein 5 | protein | 308 | 0% helix, 50% strand | P61964 |
| B | Wd repeat-containing protein 5 | protein | 9 | 33% helix, 0% strand | P61964 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 477 | 0.73 | 0.82 | 44 | SO4 |
Interfaces
1 interface between chains.
- A–B · 654 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7BED · X-ray structure of WDR5 bound to the WDR5 win motif peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61964
- Elsewhere: RCSB PDB 7BED · PDBe 7BED · UniProt P61964
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