MolNFT v1 · #173827 · protein

Cryo-EM structure of the outward open proton coupled folate transporter at pH 7.5

7BC6 · Proton-coupled folate transporter: “Cryo-EM structure of the outward open proton coupled folate transporter at pH 7.5”. Electron microscopy, 3 pockets (best druggability 0.85). MolNFT v1 #173827 on GenesisL1: 3D structure, binding…

PDB: 7BC6
Type: protein
Length: 549 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proton-coupled folate transporter; Nanobody
UniProt: E6Y8U5
Pockets: 3 · best druggability 0.85

Structure

electron microscopy · 2 distinct chains · 58% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proton-coupled folate transporter	protein	432	73% helix, 0% strand	E6Y8U5
B	Nanobody	protein	117	0% helix, 31% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1141	0.85	0.85	96	empty
2	172	0.47	0.77	28	empty
3	53	0.42	0.83	17	empty

Interfaces

1 interface between chains.

A–B · 1138 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

7BC6 · Cryo-EM structure of the outward open proton coupled folate transporter at pH 7.5 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E6Y8U5
Elsewhere: RCSB PDB 7BC6 · PDBe 7BC6 · UniProt E6Y8U5

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