MolNFT v1 · #17382 · protein

Ornithine transcarbamoylase from pseudomonas aeruginosa

1ORT: “Ornithine transcarbamoylase from pseudomonas aeruginosa”. X-ray diffraction, 20 pockets (best druggability 0.91). MolNFT v1 #17382 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ORT
Type: protein
Length: 4,020 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ornithine transcarbamoylase
EC: 2.1.3.3
UniProt: P08308
Pockets: 20 · best druggability 0.91

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L	Ornithine transcarbamoylase (EC 2.1.3.3)	protein	335	46% helix, 13% strand	P08308

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	964	0.91	0.93	111	empty
2	1114	0.90	0.92	112	empty
3	741	0.89	0.93	89	empty
4	616	0.88	0.93	74	empty
5	871	0.85	0.88	132	empty

Interfaces

30 interfaces between chains.

C–D · 1213 Å² buried · 21 hydrogen bonds · protein-protein
F–J · 1213 Å² buried · 21 hydrogen bonds · protein-protein
A–L · 1209 Å² buried · 21 hydrogen bonds · protein-protein
G–I · 1209 Å² buried · 21 hydrogen bonds · protein-protein
B–F · 1208 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

1ORT · Ornithine transcarbamoylase from pseudomonas aeruginosa · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08308
Elsewhere: RCSB PDB 1ORT · PDBe 1ORT · UniProt P08308

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