MolNFT v1 · #173808 · protein

Structure of human GEMIN6/GEMIN7/GEMIN8 trimeric complex

7BBL · Gem-associated protein 6: “Structure of human GEMIN6/GEMIN7/GEMIN8 trimeric complex”. X-ray diffraction, 2 pockets (best druggability 0.34). MolNFT v1 #173808 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7BBL
Type: protein
Length: 418 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gem-associated protein 6; Gem-associated protein 7; Gem-associated protein 8
UniProt: Q8WXD5, Q9H840, Q9NWZ8
Pockets: 2 · best druggability 0.34

Structure

x-ray diffraction · 5 distinct chains · 41% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Gem-associated protein 6	protein	85	22% helix, 42% strand	Q8WXD5
D	Gem-associated protein 7	protein	87	31% helix, 43% strand	Q9H840
E	Gem-associated protein 8	protein	39	79% helix, 0% strand	Q9NWZ8
B	Gem-associated protein 7	protein	85	32% helix, 41% strand	Q9H840
F	Gem-associated protein 8	protein	37	86% helix, 0% strand	Q9NWZ8

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.34	0.76	13	empty
2	54	0.30	0.75	11	empty

Interfaces

7 interfaces between chains.

A–B · 1329 Å² buried · 21 hydrogen bonds · protein-protein
C–D · 1328 Å² buried · 19 hydrogen bonds · protein-protein
D–E · 802 Å² buried · 7 hydrogen bonds · protein-protein
A–F · 433 Å² buried · 6 hydrogen bonds · protein-protein
B–F · 122 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7BBL · Structure of human Gemin6/Gemin7/Gemin8 trimeric complex · the same entry in another collection · chain F against F, TM-score 1.00
Q9H840 · AlphaFold monomer V2.0 prediction for gem-associated protein 7 (Q9H840) · a predicted model of the same protein · chain B against A, TM-score 0.99
Q8WXD5 · AlphaFold monomer V2.0 prediction for gem-associated protein 6 (Q8WXD5) · a predicted model of the same protein · chain A against A, TM-score 0.98
Q9NWZ8 · AlphaFold monomer V2.0 prediction for gem-associated protein 8 (Q9NWZ8) · a predicted model of the same protein · chain E against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WXD5
Every structure of UniProt Q9H840
Every structure of UniProt Q9NWZ8
Elsewhere: RCSB PDB 7BBL · PDBe 7BBL · UniProt Q8WXD5 · UniProt Q9H840 · UniProt Q9NWZ8

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